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| Home » Types of Neuropathy » Diabetic Neuropathy |
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Diabetic Neuropathy |
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Diabetic Neuropathy is a neuropathic problem that is related to damage of the nerves that occur in persons suffering from diabetes. The peripheral nerves including the sensory, motor and autonomic nerves are mostly affected in Diabetic Neuropathy. Microrvascular injuries that involve tiny blood vessels are believed to be the primary causes of Diabetic Neuropathy. Polyneuropathy, mononeuropathy, mononeuropathy multiplex, third nerve palsy and diabetic amyotrophy, thoracoabdominal neuropathy and autonomic neuropathy are some of the typical conditions that can be linked to Diabetic Neuropathy.
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Diabetes is the most common cause of neuropathy which itself the most known problem that develops mortality and morbidity in those patients who suffer from diabetes. Near about 20% of the cases that leads to neuropathy, involve the diabetic patients and Diabetic Neuropathy is connected with almost 50% to 75% of the amputations that are not the result of any physical injury. The primary risk factor which can cause Diabetic Neuropathy is known to be hyperglycemia and significantly people suffering from diabetes tend to show symptoms associated with peripheral neuropathy due to the occurrence of Glucojasinogen as a result of high level of glucose in blood. This is closely related to epigastric tenderness and erectile dysfunction that again leads to failure of blood flow to the intrapectine nerve which control the hand and feet movements.
Four important elements, which are known to be the developing factors of Diabetic Neuropathy, are microvascular disease, advanced Glycation end product, Protein kinase C and Polyol pathway. Neural and vascular diseases are associated strongly and are interconnected with each other. Vasoconstriction is the first pathological change that occurs in microvasculature and as it develops neural dysfunction gets associated with progress of vascular deformities. Raised levels of glucose within the cells lead to a covalent bonding with the protein molecules that changes their structure and destruct their function. Protein kinase C is also drawn in as a change in Diabetic Neuropathy. The high glucose levels raise the level of diacylglycerol within the cells and activate Protein kinase C. The Polyol Pathway or the Sorbitol/Aldose Reductase Pathway also cause major complications in diabetes and lead to microvascular damages to the kidney, retina and other nervous tissues.
1. Symptoms of Diabetic Neuropathy:
- Numbness
- Tingling
- Diarrhea
- Dysesthesia (leads to loss or decrease of sensitivity in a body part)
- Urinary incontinence (loss of control or control or retaining urine in the urinary bladder)
- Erectile dysfunction
- Impotence
- Sagging of face, eyelids and mouth
- Changes in vision
- Weakness in muscles
- Fasciculation (contraction of muscles)
- Dizziness
- Anorgasmia
- Speech impairment
- Dysphagia (difficulty in swallowing)
2. Treatment of Diabetic Neuropathy:
- Strict control of glucose
- Serotonin reuptake inhibitor
- Tricyclic antidepressants
- Antiepileptic medicines
3. Other treatments of Diabetic Neuropathy:
- Methylocobalamin
- a lipoic acid
You have got an idea about Diabetic Neuropathy from our site Neuropathyhub.com. If you are inquisitive enough to know more about the other types of Neuropathy just click on the other links on our site Neuropathyhub.com.
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